from secp256k1 import PublicKey
from hashlib import sha256

tx = (
  "01000000018dd4f5fbd5e980fc02f35c6ce145935b11e284605bf599a13c6d41" +
  "5db55d07a1000000008b4830450221009908144ca6539e09512b9295c8a27050" +
  "d478fbb96f8addbc3d075544dc41328702201aa528be2b907d316d2da068dd9e" +
  "b1e23243d97e444d59290d2fddf25269ee0e0141042e930f39ba62c6534ee98e" +
  "d20ca98959d34aa9e057cda01cfd422c6bab3667b76426529382c23f42b9b08d" +
  "7832d4fee1d6b437a8526e59667ce9c4e9dcebcabbffffffff0200719a818600" +
  "00001976a914df1bd49a6c9e34dfa8631f2c54cf39986027501b88ac009f0a53" +
  "62000000434104cd5e9726e6afeae357b1806be25a4c3d3811775835d235417e" +
  "a746b7db9eeab33cf01674b944c64561ce3388fa1abd0fa88b06c44ce81e2234" +
  "aa70fe578d455dac00000000"
).decode("hex")

scriptPubKey = (
  "1976a91446af3fb481837fadbb421727f9959c2d32a3682988ac"
).decode("hex")

sig = tx[0x2b:0x2b+0x47]
pub = tx[0x74:0x74+0x41]
hashType = tx[0x72]

tx = tx[:0x29] + scriptPubKey + tx[0xb5:] + hashType + "\x00\x00\x00"
hash = sha256(sha256(tx).digest()).digest()

pub = PublicKey(pub, raw=True)
sig = pub.ecdsa_deserialize(sig)
print pub.ecdsa_verify(hash, sig, raw=True)